Work

Total Synthesis of TK‐57‐164A, Isariotin F, and Their Putative Progenitor Isariotin E

Year: 2009

Type: article

Abstract: Keeping it simple: A simple strategy for the total synthesis of three complex natural products has been developed, while also confirming the putative generation of 1 and 2 from 3. The benefits of a simple dissymmetric 2,5-cyclohexadienone are illustrated and provide the foundation for rapid diastereoselective functionalization leading to the first total synthesis of these compounds.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200904716

Authors: Jacob Y. Cha, Yaodong Huang, Thomas R. R. Pettus

Institution: University of California, Santa Barbara

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Institute of General Medical Sciences

Awards: G6625719640, The Synthesis and Application of Novel Aromatic Materials