Work

Semiconducting Polymer Nanoprobe for In Vivo Imaging of Reactive Oxygen and Nitrogen Species

Year: 2013

Type: article

Abstract: Semiconducting polymer nanoparticles are used as a free-radical inert and light-harvesting nanoplatform for in vivo molecular imaging of reactive oxygen and nitrogen species (RONS). This nanoprobe permits detection of RONS in the microenvironment of spontaneous bacterial infection (see picture; FRET=fluorescence resonance energy transfer).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201303420

Authors: Kanyi Pu, Adam J. Shuhendler, Jianghong Rao

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Luminescence and Fluorescent Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Center of Cancer Nanotechnology Excellence Focused on Therapy Response, Nanoprobes for imaging RONS and drug-induced hepatotoxicity, QD-BRET nanosensors for protease detection and imaging, Nanotechnology for Multiplex Detection of Enzymes, Center for Cancer Nanotechnology Excellence and Translation (CCNE-T)