Work

Stearoyl Co-A Desaturase 1 as a ccRCC Therapeutic Target: Death by Stress

Year: 2013

Type: article

Abstract: There is a need for the discovery of novel therapeutic strategies to effectively treat advanced clear cell renal cell carcinoma (ccRCC). Inhibition of stearoyl-coA desaturase 1 (SCD1) in ccRCC reveals antitumor activity, independently and in synergy with mTOR inhibition. SCD1 may be a potential novel therapeutic target in treating ccRCC.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-13-0800

Authors: Janet Y. Leung, William Y. Kim

Institutions: University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute