Work

Detection of Histoplasma capsulatum Antigenuria by Ultrafiltration of Samples with False-Negative Results

Year: 2008

Type: article

Abstract: Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

Source: Clinical and Vaccine Immunology

DOI: 10.1128/cvi.00493-07

Authors: Lindsey Egan, Patricia A. Connolly, Deanna Fuller, Thomas E. Davis, John Witt, Kenneth S. Knox, Chadi A. Hage, L. Joseph Wheat

Institutions: Sidney & Lois Eskenazi Hospital, Richard L. Roudebush VA Medical Center, Indiana University School of Medicine

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2165730777

FWCI: 2.722

Cites: 3

Cited by: 18

Related to: 10