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Cutting Edge: MHC Class I–Ly49 Interaction Regulates Neuronal Function

Year: 2008
Type: article
Abstract: MHC class I molecules (MHC-I) have been implicated in nervous system development in the mouse. In this study we present evidence for the interaction of MHC-I with the NK cell receptor Ly49 in primary cortical neuronal cultures. We show that MHC-I and Ly49 are expressed on neuronal soma and axon surfaces, with Ly49 also present on dendrites. Anti-MHC-I Abs reduce synapsin-I expression and enhance neurite outgrowth and neuronal death. Conversely, anti-Ly49 mAbs increase synapsin-I expression, reduce neurite outgrowth, and promote neuron viability. Because we show that Ly49 genes are selectively expressed in the adult brain, these findings suggest an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain.
DOI: 10.4049/jimmunol.180.10.6447
Authors: Ofer Zohar, Yoram Reiter, Jack R Bennink, Avital Lev, Sebastiano Cavallaro, Sabrina Paratore, Chaim G Pick, Gary Brooker, Jonathan W Yewdell
Institutions: Johns Hopkins University, Blanchette Rockefeller Neurosciences Institute, Technion – Israel Institute of Technology, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Institute of Neurological Sciences, National Research Council, Tel Aviv University
Language: English
Subfield: Immunology
Open Access status: bronze
OpenAlex ID: W2165761277
FWCI: 2.503
Cites: 19
Cited by: 49
Related to: 10