Changes in mood, depression and suicidal ideation after commencing pregabalin for neuropathic pain.
Year: 2014
Type: article
Study design: Case Report
Abstract: BACKGROUND: Pregabalin is a treatment option for patients with persistent neuropathic pain. Its use has been associated with changes in mood and the development of depression and/or suicidal ideation. OBJECTIVE: Case presentations were reviewed of five patients reporting changes in mood, depression and suicidal ideation from the first 50 (approximately) patients commenced on pregabalin at the clinic. DISCUSSION: Although these patients had a history of depression, their mood had been stable before commencing pregabalin. Soon after commencement they reported changes in mood, and development of depression and/or suicidal ideation, which improved with dose reduction or cessation of pregabalin. Ultimately, all five patients ceased pregabalin treatment. Suicidal ideation is a recognised adverse effect of pregabalin. Patients should be warned of and monitored for deterioration in mood.
Source: PubMed
Authors: Tony David Hall, Simon Shah, Bradley Ng, Heide Marie Feberwee, Leigh Dotchin, Margaret Vandermost, Michelle A King
Institutions: Griffith University, Gold Coast Hospital, Gold Coast Health
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Pfizer, Nevro, Pfizer Australia, Servier
OpenAlex ID: W2165802556