Low-coherence enhanced backscattering: review of principles and applications for colon cancer screening
Year: 2006
Type: article
Abstract: The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering (CBS) of light, has been the object of intensive investigation in nonbiological media over the last two decades. However, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements in tissue by taking advantage of low spatial coherence illumination, which has led us to the development of low-coherence enhanced backscattering (LEBS) spectroscopy. In this work, we review the current state of research on LEBS. After a brief discussion of the basic principle of EBS and LEBS, we present an overview of the unique features of LEBS for tissue characterization, and show that LEBS enables depth-selective spectroscopic assessment of mucosal tissue. Then, we demonstrate the potential of LEBS spectroscopy for predicting the risk of colon carcinogenesis and colonoscopy-free screening for colorectal cancer (CRC).
Source: Journal of Biomedical Optics
DOI: 10.1117/1.2236292
Institution: Northwestern University
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: CAREER: Optical Spectroscopy and Imaging for Understanding the Interrelation of Molecular and Ultrastructural Changes in Neoplastic Cells and Early Cancer Detection, Spectroscopic Markers to Risk-Stratify Colonic Neoplasia, G539524280, G6267338311, Mechanisms of Light Scattering in Living Tissue, G9000211584
OpenAlex ID: W2165845406