Work

DNA-Mediated Transfer of a Human Gene Required for Low-Density Lipoprotein Receptor Expression and for Multiple Golgi Processing Pathways

Year: 1986

Type: article

Abstract: Transfection of a hamster cell mutant with human DNA corrected both the low-density lipoprotein receptor-deficient phenotype and the multiple glycosylation defects of the cells. Independently transfected colonies contained a small set of common human DNA fragments. These fragments may correspond to the human analog of a single gene required for several different Golgi processing pathways.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.6.7.2734

Authors: D M Kingsley, R D Sege, K F Kozarsky, M Krieger

Institution: Massachusetts Institute of Technology

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health