Allospecificity of liver allograft-derived lymphocytes and correlation with clinicopathologic findings.
Year: 1988
Type: article
Study design: Observational Study
Abstract: P REVIOUS studies have shown that acti vated T cells can be propagated in vitro from liver allograft biopsies in presence of exogenous recombinant IL 2. Further analysis of these biopsy-grown lymphocytes has revea led the presence of alloreactive T cells specific for donor HLA antigens. Often enough, these cell cultures exhibit restricted specificity patterns against one or few of the donor HLA antigens. This alloreactivity could also be blocked with monoclonal antibodies (MoAb) against appropriate HLA determi nants,u Similar observations have also been made on lymphocyte cultures grown from heart transplant biopsies. In certain patients, there appeared a sequential infiltration of the allograft by class I-specific lymphocytes in earlier biopsies followed by class II- or mixed class l/ll-specific lymphocytes in later biop sies. 3 The aim of this study was to evaluate the association of the HLA class I and class II allospecificity of lymphocytes grown from liver allograft biopsies with clinical, biochemi cal, and histopathologic findings.
Source: PubMed
Institution: University of Pittsburgh
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2166032066