Work

Proinflammatory and Antimicrobial Nitric Oxide in Gingival Fluid of Diabetic Patients with Periodontal Disease

Year: 2006

Type: article

Abstract: Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO.

Source: Infection and Immunity

DOI: 10.1128/iai.00071-06

Authors: Uros Skaleric, Boris Gaspirc, Nancy McCartney-Francis, Andrej Masera, Sharon M. Wahl

Institutions: University of Ljubljana, National Institutes of Health, National Institute of Dental and Craniofacial Research

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health