Work

P‐Glycoprotein‐Dependent Trafficking of Nanoparticle‐Drug Conjugates

Year: 2014

Type: article

Abstract: P-glycoprotein (P-gp) is considered to be the most prevalent and single most important cause of multidrug-resistance (MDR) in humans. Although the protein is well known to modulate the cellular trafficking of small molecule fluorophores, antimicrobials, and up to 50% of all cytotoxic chemotherapeutics, little is known about its interactions with nanoscale drug conjugates. Here, we use P-gp substrate-conjugated gold nanorods as model drug carriers to investigate P-gp-dependent cellular trafficking of nanoparticles.

Source: Small

DOI: 10.1002/smll.201303190

Authors: Erik C. Dreaden, Idris O. Raji, Lauren A. Austin, Shaghayegh Fathi, Sandra C. Mwakwari, William H. Humphries, Bin Kang, Adegboyega K. Oyelere, Mostafa A. El‐Sayed

Institution: Georgia Institute of Technology

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: G1067586170, LbL Nanotechnologies for Synergistic Therapy of Advanced Ovarian Carcinoma, Nonpeptide macrocyclic histone deacetylase (HDAC) inhibitors for targeted lung ca, Toxicity and Efficacy of Gold Nanoparticle Photothermal Therapy in Cancer, G8384579504

OpenAlex ID: W2166055479

FWCI: 1.125

Cites: 49

Cited by: 18

Related to: 10