Work

Transforming growth factor beta in Alzheimer's disease

Year: 1994

Type: article

Abstract: Alzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD patients < 6 h after death. Serum TGF-beta levels were also markedly elevated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically mediated neuronal injury.

Source: Clinical and Diagnostic Laboratory Immunology

DOI: 10.1128/cdli.1.1.109-110.1994

Authors: C C Chao, S Hu, W H Frey, T A Ala, W W Tourtellotte, P K Peterson

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Center for Research Resources

Award: BIOMEDICAL RESEARCH SUPPORT GRANT