Work

Polycystic Ovaries and Polycystic Ovary Syndrome in Epilepsy: Evidence for Neurogonadal Disease

Year: 2005

Type: article

Abstract: Polycystic ovary syndrome (PCOS) is a mysterious reproductive disorder that results in subfertility. The underlying causes are not known, and even the definition is a moving target. Women with epilepsy have features of PCOS at a higher than expected rate, and polycystic ovaries (PCO) also are present at high rates in this population. Valproate is associated with weight gain and increased androgen levels, two features of PCOS. This review proposes that epilepsy, with its known adverse effects on luteinizing hormone pulsatility, could be a cause of PCOS and that valproate could be an imitator, if not also a cause of the syndrome.

Source: Epiliepsy currents/Epilepsy currents

DOI: 10.1111/j.1535-7511.2005.00039.x

Author: Cynthia L. Harden

Institutions: NewYork–Presbyterian Hospital, Cornell University, Weill Cornell Medical Center

Language: English

Topic: Ovarian function and disorders

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2166111828

FWCI: 1.758

Cites: 34

Cited by: 34

Related to: 10