Work

Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach

Year: 2003

Type: article

Abstract: The genome of Mycobacterium tuberculosis was analyzed using recently developed computational approaches to infer protein function and protein linkages. We evaluated and employed a method to infer genes likely to belong to the same operon, as judged by the nucleotide distance between genes in the same genomic orientation, and combined this method with those of the Rosetta Stone, Phylogenetic Profile and conserved Gene Neighbor computational methods for the inference of protein function.

Source: Genome biology

DOI: 10.1186/gb-2003-4-9-r59

Authors: Michael Strong, Parag Mallick, Matteo Pellegrini, Michael J Thompson, David Eisenberg

Institutions: Howard Hughes Medical Institute, University of California, Los Angeles

Language: English

Topic: Genomics and Phylogenetic Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,490

Funders: U.S. Public Health Service, National Institute of General Medical Sciences