Work

Linking abnormal mitosis to the acquisition of DNA damage

Year: 2012

Type: review

Abstract: Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks. Consequently, deregulated cell division can devastate the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote transformation. Recent work has shed light on the mechanisms that link abnormal mitosis with the development of DNA damage, how cells respond to such affronts, and the potential impact on tumorigenesis.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201210040

Authors: Neil J. Ganem, David Pellman

Institutions: Howard Hughes Medical Institute, Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Howard Hughes Medical Institute, National Cancer Institute, National Institute of General Medical Sciences