Year: 2011
Type: article
Abstract: The ID family of helix-loop-helix proteins regulates cell proliferation and differentiation in many different developmental pathways, but the functions of ID4 in mammary development are unknown. We report that mouse Id4 is expressed in cap cells, basal cells and in a subset of luminal epithelial cells, and that its targeted deletion impairs ductal expansion and branching morphogenesis as well as cell proliferation induced by estrogen and/or progesterone. We discover that p38MAPK is activated in Id4-null mammary cells. p38MAPK is also activated following siRNA-mediated Id4 knockdown in transformed mammary cells. This p38MAPK activation is required for the reduced proliferation and increased apoptosis in Id4-ablated mammary glands. Therefore, ID4 promotes mammary gland development by suppressing p38MAPK activity.
Source: Development
DOI: 10.1242/dev.069203
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G1466887737, PROGENITOR CELLS AND ONCOGENE TARGETS IN BREAST CANCER, BD Biosciences Special Order LSRII, G2408992657, G277360231, G3783386658, G422099873, G4440627923, G513002785, G746461529, Regulation of Mammary Stem Cells, G8059554933, G863484009, G8678457889, G8832621192, G8943344414, G9000052982, G9000198215, G9000290276, Baylor College of Medicine Cancer Center - Cancer Center Support Grant, G99424851
OpenAlex ID: W2166487539