Work

Recruitment of RNA polymerase III to its target promoters

Year: 2002

Type: preprint

Abstract: A key step in retrieving the information stored in the complex genomes of eukaryotes involves the identification of transcription units and, more specifically, the recognition of promoter sequences by RNA polymerase. In eukaryotes, the task of recognizing nuclear gene promoters and then transcribing the genes is divided among three highly related enzymes, RNA polymerases I, II, and III. Each of these RNA polymerases is dedicated to the transcription of specific sets of genes, and each depends on accessory factors, the so-called transcription factors, to recognize its cognate promoter sequences.

Source: Genes & Development

DOI: 10.1101/gad.1018902

Authors: Laura Schramm, Nouria Hernandez

Institutions: Howard Hughes Medical Institute, Cold Spring Harbor Laboratory

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Institute of General Medical Sciences

Awards: G2137377738, Expression of snRNA genes