Work

An Introduction to Sequence Similarity (“Homology”) Searching

Year: 2013

Type: article

Abstract: Sequence similarity searching, typically with BLAST, is the most widely used and most reliable strategy for characterizing newly determined sequences. Sequence similarity searches can identify "homologous" proteins or genes by detecting excess similarity- statistically significant similarity that reflects common ancestry. This unit provides an overview of the inference of homology from significant similarity, and introduces other units in this chapter that provide more details on effective strategies for identifying homologs.

Source: Current Protocols in Bioinformatics

DOI: 10.1002/0471250953.bi0301s42

Author: William R. Pearson

Institution: University of Virginia

Language: English

Topic: Genomics and Phylogenetic Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: U.S. National Library of Medicine

Award: Comparison of Protein Sequences and Structures