Year: 2008
Type: article
Abstract: Accumulating data suggest that not all human immunodeficiency virus (HIV)-1-specific immune responses are equally effective at controlling HIV-1 replication. A new study now demonstrates that multiple immune-driven sequence polymorphisms in the highly conserved HIV-1 Gag region of transmitted viruses are associated with reduced viral replication in newly infected humans. These data suggest that targeting these and other conserved viral regions may be the key to developing an effective HIV-1 vaccine.
DOI: 10.1084/jem.20080569
Authors: Todd M. Allen, Marcus Altfeld
Institutions: Harvard University, Massachusetts General Hospital
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2166710727