Work

Merlin in organ size control and tumorigenesis: Hippo versus EGFR?

Year: 2010

Type: preprint

Abstract: The role of the NF2 gene as a tumor suppressor has been well established. In this issue of Genes & Development, Benhamouche and colleagues (pp. 1718-1730) demonstrate that NF2 is also involved in the regulation of organ size control in mammals. Conditional knockout of Nf2 in the mouse liver results in massive organ enlargement and eventual tumor development, which is attributed to the specific expansion of oval cells. Here we discuss these findings and the proposed molecular mechanisms involved within the context of our current understanding of the pathways regulated by NF2.

Source: Genes & Development

DOI: 10.1101/gad.1964810

Authors: Chunling Yi, Joseph L. Kissil

Institution: The Wistar Institute

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: American Cancer Society, Children's Tumor Foundation, National Institutes of Health, National Cancer Institute