Work

Active and latent forms of transforming growth factor beta activity in synovial effusions.

Year: 1989

Type: article

Abstract: We have evaluated the possible involvement of TGF-beta in rheumatoid arthritis by assay of 16 cell-free synovial fluids for the presence of its active and "latent" forms. Evidence has been obtained for TGF-beta-like activity in synovial effusions by four criteria: (a) TGF-beta receptor competition, (b) soft-agar colony formation of AKR-2B and NRK-49F indicator cells, (c) immunological neutralization of the biological activity, and (d) biochemical activation of a latent form.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.169.1.291

Authors: R Fava, N Olsen, J Keski-Oja, H Moses, T Pincus

Institution: Vanderbilt University

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute