Work

Synthesis of Size‐Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single‐Layer Microchannels

Year: 2011

Type: article

Abstract: A versatile microfluidic platform to synthesize NPs by nanoprecipitation using 3D hydrodynamic flow focusing isolates the precipitating precursors from channel walls, eliminating fouling of the channels. It is shown that this new method enables robust nanoprecipitation without polymer aggregation, regardless of the polymer molecular weight or precursor concentration implemented, where the size of the resulting polymeric NPs is tunable.

Source: Advanced Materials

DOI: 10.1002/adma.201004333

Authors: Minsoung Rhee, Pedro M. Valencia, Maria I. Rodriguez, Robert Langer, Omid C. Farokhzad, Rohit Karnik

Institutions: Brigham and Women's Hospital, Harvard University, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering