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Emerging insights into the molecular and cellular basis of glioblastoma

Year: 2012
Type: preprint
Abstract: Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.
DOI: 10.1101/gad.187922.112
Authors: Gavin P. Dunn, Mikael L. Rinne, Jill Wykosky, Giannicola Genovese, Steven N. Quayle, Ian F. Dunn, Pankaj K. Agarwalla, Milan G. Chheda, Benito Campos, Alan Wang, Cameron Brennan, Keith L. Ligon, Frank Furnari, Webster K. Cavenee, Ronald A. Depinho, Lynda Chin, William C. Hahn
Institutions: Broad Institute, Harvard University, Massachusetts General Hospital, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, Center for Neuro-Oncology, University of California San Diego, Brigham and Women's Hospital, Memorial Sloan Kettering Cancer Center, Heidelberg University, The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Genetics
Field: Medicine
Open Access status: diamond
Funders: American Brain Tumor Association, National Foundation for Cancer Research, Goldhirsh Foundation, Sontag Foundation, Ben and Catherine Ivy Foundation, Brain Science Foundation, National Institutes of Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke
Awards: Mechanisms of Glioma Resistance to EGFR Inhibition, Therapeutic Opportunities for Pediatric Astrocytoma, G1864703947, G2757605240, G3146183854, G3305534244, G3746145884, G4612228525, G6247146851, G6671539959, Characterization of GEFT AS a Novel Glioblastoma Oncogene, G9000061708, Genetics and Biology of Pancreatic Ductal Adenocarcinoma
OpenAlex ID: W2166798417
Cites: 368
Cited by: 565
Related to: 10