Work

Acellular Biomaterials: An Evolving Alternative to Cell-Based Therapies

Year: 2013

Type: article

Abstract: Acellular biomaterials can stimulate the local environment to repair tissues without the regulatory and scientific challenges of cell-based therapies. A greater understanding of the mechanisms of such endogenous tissue repair is furthering the design and application of these biomaterials. We discuss recent progress in acellular materials for tissue repair, using cartilage and cardiac tissues as examples of applications with substantial intrinsic hurdles, but where human translation is now occurring.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.3003997

Authors: Jason A. Burdick, Robert L. Mauck, Joseph H. Gorman, Robert C. Gorman

Institution: University of Pennsylvania

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute