Role of the Conformational Rigidity in the Design of Biomimetic Antimicrobial Compounds
Year: 2010
Type: article
Abstract: When structural flexibility is a plus: A link between structural flexibility of biomimetic antimicrobials and their ability to penetrate into the hydrophobic core and disrupt the integrity of bacterial lipid model membranes has been established using liquid surface X-ray scattering techniques. Results indicate that the modes of interaction of flexible and conformationally restrained antimicrobials with the bacterial membranes are different (see picture).
Authors: Andrey Ivankin, Liran Livne, Amram Mor, Gregory A. Caputo, William F. DeGrado, Mati Meron, Binhua Lin, David Gidalevitz
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2166874664