Year: 2013
Type: article
Abstract: Background Nucleosome survival during transcription is important for the maintenance of chromatin integrity, gene regulation, cell survival, and aging. In according to the studies in vitro and in vivo, Pol II pauses at positions inside of a nucleosome and nucleosome survives after Pol II transcription through chromatin [1]. A key intermediate, O-loop (EC+49), formed at +45 region inside of nucleosome and Pol II pausing at +45 nucleosomal region positively correlated to nucleosome survival [2,3]. A putative electrostatic interaction between Pol II and histone octamer has also been predicted to stabilize the O-loop intermediate by structural modeling [3]. In this study, we will provide more evidences to link those characteristics together.
Source: Epigenetics & Chromatin
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,190
OpenAlex ID: W2166904356