Work

Immune role of hepatic TLR-4 revealed by orthotopic mouse liver transplantation

Year: 2006

Type: article

Abstract: UNLABELLED: Activated CD8+ T cells migrate to the liver at the end of an immune response and go through apoptosis there, but this mechanism is impaired in mice lacking Toll-like receptor-4. This allowed us to test the importance of liver trapping in an ongoing immune response. In the absence of Toll-like receptor-4, reduced liver accumulation was associated with an increase in the circulating CD8+ T cell pool, more long-lived memory T cells and increased CD8+ T cell memory responses. Using experimental orthotopic liver transplantation, we showed that the effect of Toll-like receptor-4 on the formation of the CD8+ T cell memory resides in the liver. CONCLUSION: These studies reveal a new function for the liver, which is to regulate the magnitude of T cell memory responses through a Toll-like receptor-4-dependent mechanism.

Source: Hepatology

DOI: 10.1002/hep.21446

Authors: Beena John, Ingo Klein, Nicholas I. Crispe

Institutions: University of Rochester Medicine, University of Rochester, University of Würzburg, Universitätsklinikum Würzburg

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Allergy and Infectious Diseases