Work

Draft Genome Sequence of Escherichia coli Strain Nissle 1917 (Serovar O6:K5:H1)

Year: 2013

Type: article

Abstract: We announce the availability of the 5.023-Mbp high-quality draft assembly of the Escherichia coli strain Nissle 1917 (serovar O6:K5:H1) genome. Short genomic segments from this important probiotic strain have been available in public databases, but the full genome sequence has remained inaccessible. Thus, high-coverage, whole genome sequencing of E. coli Nissle 1917 is presented herein. Reannotation and metabolic reconstruction will enable comparative genomics analysis and model-guided predictions of genetic manipulations leading to increased production of the K5 capsular polysaccharide known as N-acetyl heparosan, a precursor to the anticoagulant pharmaceutical heparin.

Source: Genome Announcements

DOI: 10.1128/genomea.00047-13

Authors: Brady F. Cress, Robert J. Linhardt, Mattheos A. G. Koffas

Institution: Rensselaer Polytechnic Institute

Language: English

Topic: Escherichia coli research studies

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Rensselaer Polytechnic Institute, Weill Cornell Medical College