Work

The Origins and Implications of Intratumor Heterogeneity

Year: 2010

Type: article

Abstract: Human tumors often display startling intratumor heterogeneity in various features including histology, gene expression, genotype, and metastatic and proliferative potential. This phenotypic and genetic heterogeneity plays an important role in neoplasia, cancer progression, and therapeutic resistance. In this issue of the journal (beginning on page 1388), Merlo et al. report their use of molecular data from 239 patients with Barrett's esophagus to evaluate the propensity of major diversity indices for predicting progression to esophageal adenocarcinoma. This work helps elucidate the implications of molecular heterogeneity for the evolution of neoplasia.

Source: Cancer Prevention Research

DOI: 10.1158/1940-6207.capr-10-0234

Authors: Franziska Michor, Kornelia Polyak

Institutions: Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute