Work

Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α‐Trifluoromethyl Carbonyl Compounds

Year: 2011

Type: article

Abstract: A facile and efficient method for the α-trifluoromethylation of carbonyl compounds and enolsilanes has been accomplished through application of a photoredox catalysis strategy. A one-flask procedure for the direct α-trifluoromethylation and α-perfluoroalkylation of ketone, amide, and ester substrates as well as silylketene acetals is described (see scheme).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201101861

Authors: Phong V. Pham, David A. Nagib, David W. C. MacMillan

Institution: Princeton University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: New Strategies in Metallaphotoredox Catalysis