Work

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease

Year: 2005

Type: article

Study design: Observational Study

Abstract: Although it is clear that microtubule associated protein tau (MAPT) is involved in Alzheimer's disease (AD) pathology, it has not been clear whether it is involved genetically. We have recently examined the MAPT locus in progressive supranuclear palsy and found that a haplotype (H1c) on the background of the well-described H1 clade is associated with PSP. Here we report that the same haplotype is associated with the risk of AD in two autopsy confirmed series of cases with ages at death >65 years.

Source: Human Molecular Genetics

DOI: 10.1093/hmg/ddi241

Authors: A.J. Myers, M. Kaleem, L. Marlowe, A.M. Pittman, A.J. Lees, H.C. Fung, J. Duckworth, D. Leung, A. Gibson, C.M. Morris, R. de Silva, J. Hardy

Institutions: National Institutes of Health, National Institute on Aging, University College London, Chang Gung University, Newcastle upon Tyne Hospitals NHS Foundation Trust

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke

Awards: G1322720882, G1591652791, G2038718543, UCLA Alzheimer's Disease Research Center, ALZHEIMER'S DISEASE RESEARCH CENTER, Michigan Alzheimer's Disease Research Center, Johns Hopkins Alzheimer's Disease Research Center, G800620756, The Genetics of Parkinsonism, Conte Centers for the Neuroscience of Depression

OpenAlex ID: W2167141135

FWCI: 11.79

Cites: 20

Cited by: 222

Related to: 10