Work

Mode of Action of Diterpene and Characterization of Related Metabolites from the Soft Coral, Xenia elongata

Year: 2014

Type: article

Abstract: Chemical and biological investigation of the cultured marine soft coral Xenia elongata led to the isolation of two new diterpenes (2, 3). Their structures were elucidated using a combination of NMR and mass spectrometry. Biological evaluations and assessments were determined using the specific apoptosis induction assay based on genetically engineered mammalian cell line D3 deficient in Bak and Bax and derived from a mouse epithelial cell. The diterpenes induce apoptosis in low micromolar concentrations. The results indicate that the previously isolated compound (1) affects cell in a manner similar to that of HSP90 and HDAC inhibitors and in a manner opposite of PI3 kinase/mTOR inhibitors. Compound (3) inhibits selectively HDAC6 in high micromolar concentrations.

Source: Marine Drugs

DOI: 10.3390/md12021102

Authors: Eric Andrianasolo, Liti Haramaty, Eileen White, Richard Lutz, Paul Falkowski

Institutions: Rutgers, The State University of New Jersey, Rutgers Cancer Institute

Language: English

Topic: Marine Sponges and Natural Products

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499