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Pharmacoeconomics of Hematopoietic Stem Cell Mobilization: An Overview of Current Evidence and Gaps in the Literature

Year: 2013
Type: article
Abstract: Adequate hematopoietic stem cell (HSC) mobilization and collection is required prior to proceeding with high dose chemotherapy and autologous hematopoietic stem cell transplant. Cytokines such as G-CSF, GM-CSF, and peg-filgrastim, alone or in combination with plerixafor, and after chemotherapy have been used to mobilize HSCs. Studies have shown that the efficiency of HSC mobilization and collection may vary when different methods of mobilization are used. No studies have shown that survival is significantly affected by the method of mobilization, but some studies have suggested that cost and resource utilization may be different between different mobilization techniques. After the FDA approval of plerixafor with G-CSF to mobilize HSCs many transplant centers became concerned about the cost of HSC mobilization. A panel of experts was convened ant this paper reviews the current literature on the pharmacoeconomics of HSC mobilization.
DOI: 10.1016/j.bbmt.2013.05.008
Authors: Paul Shaughnessy, Nelson Chao, Jamie Shapiro, Kent Walters, John McCarty, Sunil Abhyankar, Sepideh Shayani, Pieter Helmons, Helen Leather, Amy Pazzalia, Simon Pickard
Institutions: Military Health System, Duke Medical Center, The University of Texas MD Anderson Cancer Center, Virginia Commonwealth University, University of Kansas Medical Center, City of Hope, University Medical Center Groningen, University of Florida, University of Illinois Chicago
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2167328704
FWCI: 1.487
Cites: 83
Cited by: 26
Related to: 10