Extravascular penetration of tobramycin and netilmicin in a subcutaneous visking chamber model in rabbits
Year: 1983
Type: article
Abstract: Netilmicin and tobramycin penetration in a rabbit Visking chamber model was studied after administration of multiple intramuscular doses of 2 mg of either drug per kg every 4 h in a double-crossover design. The mean serum half-life, mean peak concentration in serum, and mean area under the plasma concentration curve were similar. The mean peak concentration in the chamber and mean area under the plasma concentration curve were likewise not significantly different.
DOI: 10.1128/aac.24.4.594
Authors: T A Larson, D N Gerding, L R Peterson
Institutions: University of Minnesota, Minneapolis VA Medical Center
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2167583891