Work

Optimization of 3-D image-guided near infrared spectroscopy using boundary element method

Year: 2009

Type: conference-paper

Abstract: Multimodality imaging systems combining optical techniques with MRI/CT provide high-resolution functional characterization of tissue by imaging molecular and vascular biomarkers. To optimize these hybrid systems for clinical use, faster and automatable algorithms are required for 3-D imaging. Towards this end, a boundary element model was used to incorporate tissue boundaries from MRI/CT into image formation process. This method uses surface rendering to describe light propagation in 3-D using diffusion equation. Parallel computing provided speedup of up to 54% in time of computation. Simulations showed that location of NIRS probe was crucial for quantitatively accurate estimation of tumor response. A change of up to 61% was seen between cycles 1 and 3 in monitoring tissue response to neoadjuvant chemotherapy.

Source: IEEE International Symposium on Biomedical Imaging (ISBI)

DOI: 10.1109/isbi.2009.5193242

Authors: Subhadra Srinivasan, Colin Carpenter, Brian W. Pogue, Keith D. Paulsen

Institution: Dartmouth College

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering