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Restricted Varicella-Zoster Virus Transcription in Human Trigeminal Ganglia Obtained Soon after Death

Year: 2012
Type: article
Abstract: We analyzed the varicella-zoster virus (VZV) transcriptome in 43 latently infected human trigeminal ganglia (TG) with postmortem intervals (PMIs) ranging from 3.7 to 24 h. Multiplex reverse transcriptase PCR (RT-PCR) revealed no VZV transcripts with a PMI of <9 h. Real-time PCR indicated a significant increase (P = 0.02) in VZV ORF63 transcript levels but not the virus DNA burden with longer PMI. Overall, both the breadth of the VZV transcriptome and the VZV ORF63 transcript levels in human cadaver TG increased with longer PMI.
DOI: 10.1128/jvi.01331-12
Authors: Werner J. D. Ouwendijk, Alexander Choe, Maria A. Nagel, Don Gilden, Albert D. M. E. Osterhaus, Randall J. Cohrs, Georges M. G. M. Verjans
Language: English
Subfield: Epidemiology
Field: Medicine
Open Access status: bronze
Awards: G2067019110, G527177068, G5535863426, G5577633599, A major contributor of serious multisystem disease in the elderly: varicella zoster virus-induced inflammation, G8134191220, G8349630629
OpenAlex ID: W2167617229
FWCI: 3.659
Cites: 17
Cited by: 67
Related to: 10