Externally validated predictive clinical model for untreated del(17p13.1) chronic lymphocytic leukemia patients
Year: 2015
Type: article
Study design: Observational Study
Abstract: Little is known about outcomes of patients with chronic lymphocytic leukemia (CLL) with del(17p13.1) karyotype at diagnosis. We reviewed 114 de novo del(17p13.1) CLL patients seen at our institution. Using proportional hazards models to identify pretreatment clinical variables significantly associated with treatment-free survival (TFS) and overall survival (OS), we developed a simplified risk score for de novo del(17p13.1) CLL patients to predict TFS and OS based on these variables. These scores, particularly the very highest, can be utilized to identify high-risk patients for expedient enrollment on clinical trials. Our data support careful observation for low-risk patients, potentially preventing unnecessary use of aggressive therapies.
Source: American Journal of Hematology
DOI: 10.1002/ajh.24125
Authors: Deborah M. Stephens, Amy S. Ruppert, William G. Weirda, Jeffrey A. Jones, Jennifer A. Woyach, Kami Maddocks, Samantha M. Jaglowski, Leslie A. Andritsos, Joseph M. Flynn, Michael R. Grever, Gerard Lozanski, Constantine Tam, Susan O'Brien, Michael J. Keating, Natarajan Muthusamy, Lynne V. Abruzzo, Nyla A. Heerema, John C. Byrd
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2167621697