Year: 2008
Type: editorial
Abstract: E xisting guidelines for screening and managing lipopro- tein abnormalities in children and adolescents are based on a consensus document published over 15 years ago by the National Cholesterol Education Program (NCEP) Expert Panel on Blood Cholesterol Levels in Children and Adolescents. 1 This document was based on evidence that elevated levels of low-density lipoprotein (LDL) cholesterol are highly correlated with development of atherosclerotic cardiovascular disease (ASCVD) in adults and on pathological data suggesting that dyslipidemia in children and adolescents was associated with early arterial plaque development.The panel recommended 2 strategies to address abnormal lipoprotein levels in children: a population-based approach (dietary recommendations) and a targeted screening approach (selective screening based on family history of ASCVD and/or parental hypercholesterolemia).The guidelines recommended dietary and lifestyle interventions for children with elevated LDL cholesterol levels.They proposed that drug therapy only be considered when LDL cholesterol levels are Ն190 mg/dL or Ն160 mg/dL with concomitant ASCVD risk factors (Ն2) or with a family history of ASCVD.
Source: Circulation
Authors: Julia Steinberger, Aaron S. Kelly
Institution: University of Minnesota
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2167736042