Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development
Year: 2010
Type: article
Abstract: Within the European Immunogenicity Platform (EIP) ( http://www.e-i-p.eu ), the Protein Characterization Subcommittee (EIP-PCS) has been established to discuss and exchange experience of protein characterization in relation to unwanted immunogenicity. In this commentary, we, as representatives of EIP-PCS, review the current state of methods for analysis of protein aggregates. Moreover, we elaborate on why these methods should be used during product development and make recommendations to the biotech community with regard to strategies for their application during the development of protein therapeutics.
Source: Pharmaceutical Research
Authors: John den Engelsman, Patrick Garidel, Ronald Smulders, Hans Koll, Bryan Smith, Stefan Bassarab, Andreas Seidl, Otmar Hainzl, Wim Jiskoot
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,690
OpenAlex ID: W2167777181