Mammalian RAD23 homologs: multifunctional. proteins in DNA repair and development
Year: 2001
Type: dissertation
Abstract: Preservation of an intact genome is of utmost importance to all living\norganisms. However. the integrity of DNA. the carrier of genetic information\nrequired for proper functioning of cellular processes. is continuously\nchallenged. Cells must overcome endogenous (metabolic) and exogenous\n(environmental) threats, as well as the intrinsic instability of chemical\nbonds in DNA itself (e.g. deamination and depurination). Oxidative stress.\nultraviolet (UV) light. ionizing radiation (X-rays). and numerous chemicals\ninduce a wide variety of lesions in the DNA. DNA damage can affect cellular\nprocesses and can have severe consequences for human health. Its direct\neffect at the cellular level is inhibition of vital processes like transcription\nand replication resulting in cell cycle arrest. Accumulation of lesions in DNA\nabove certain thresholds can lead either to (programmed) cell death by\napoptosis or to permanent alterations in the genetic code (mutations). These\nmutations can in turn ca
Author: Jessica M.Y. Ng
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2167801827