Work

Tracing the origins of centrioles, cilia, and flagella

Year: 2011

Type: review

Abstract: Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral structures; they are present in all major eukaryotic groups. Despite the conservation of their core structure, there is variability in their architecture, function, and biogenesis. Recent genomic and functional studies have provided insight into the evolution of the structure and function of these organelles.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.201011152

Authors: Zita Carvalho-Santos, Juliette Azimzadeh, José. B. Pereira-Leal, Mónica Bettencourt-Dias

Institutions: Instituto Gulbenkian de Ciência, University of California, San Francisco

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: Fundação para a Ciência e a Tecnologia

Awards: Regulação Da Biogénese E Função Dos Centriolos, Uma Visão Integrativa, Regulação da formação de cilios e flagelos, G4508731996