Work

Haptens can serve as surrogate transplantation antigens in a manner that demonstrates H-2 restriction of graft rejection.

Year: 1983

Type: article

Abstract: Hapten-immune mice are capable of rejecting syngeneic skin grafts that are derivatized with the relevant hapten, but only if the hapten is applied while the graft is "healing in." This model system was used to demonstrate that the hapten-specific immune effectors responsible for rejection are restricted by H-2 determinants of the recipient. Thus, haptens can be used in vivo as surrogate transplantation antigens for the study of immunopathogenic mechanisms in transplantation immunity.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.157.4.1354

Authors: J W Streilein, P R Bergstresser

Institutions: The University of Texas Southwestern Medical Center, University of Texas Health Science Center at Dallas

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2167861472