Year: 2015
Type: article
Abstract: BACKGROUND: Host genetic variability has been implicated in chemotherapy-induced peripheral neuropathy (CIPN). A dose-limiting toxicity for chemotherapy agents, CIPN is also a debilitating condition that may progress to chronic neuropathic pain. We utilized a bioinformatics approach, which captures the complexity of intracellular and intercellular interactions, to identify genes for CIPN. METHODS: Using genes pooled from the literature as a starting point, we used Ingenuity Pathway Analysis (IPA) to generate gene networks for CIPN. RESULTS: We performed IPA core analysis for genes associated with platinum-, taxane- and platinum-taxane-induced neuropathy. We found that IL6, TNF, CXCL8, IL1B and ERK1/2 were the top genes in terms of the number of connections in platinum-induced neuropathy and TP53, MYC, PARP1, P38 MAPK and TNF for combined taxane-platinum-induced neuropathy. CONCLUSION: Neurotoxicity is common in cancer patients treated with platinum compounds and anti-microtubule agents and CIPN is one of the debilitating sequela. The bioinformatic approach helped identify genes associated with CIPN in cancer patients.
Source: BioData Mining
Institution: The University of Texas MD Anderson Cancer Center
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: Innovative Multidisciplinary Education: The Statistical Genetics of Addiction, G1901027039, Using Deep Sequencing Technology to Study Genes & Behavioral Phenotypes Related to Smoking Cessation, Negative affect & Nicotine Withdrawal, Method to analyze X-chromosomal genetic data, Genome Wide Association Study of Head and Neck Cancer, G6736661663, Molecular Epidemiology of Neuropathic Pain in Head and Neck Cancer, G788993117, G9000284475, Cancer Center Support Grant
OpenAlex ID: W2167905862