Work

A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization.

Year: 1977

Type: article

Abstract: AM-2282, a new alkaloid has been isolated from cultures of Streptomyces sp. AM-2282 by solvent extraction and silica gel chromatography. The compound exhibits a strong absorption maximum at 292 nm and shows antimicrobial activity against fungi and yeast. The LD50 of its hydrochloride (i.p. in mice) is 6.6 mg/kg. The molecular formula of AM-2282 has been determined as C28H26N4O3. The producing strain, AM-2282 was classified as a new species and the name, Streptomyces staurosporeus AWAYA, TAKAHASHI and OMURA, nov. sp. is proposed.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.30.275

Authors: SATOSHI OMURA, YUZURU IWAI, ATSUSHI HIRANO, AKIRA NAKAGAWA, JUICHI AWAYA, HISAE TSUCHIYA, YOKO TAKAHASHI, ROKUROU ASUMA

Institution: Kitasato University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2167944112

FWCI: 0.46

Cites: 15

Cited by: 688

Related to: 9