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Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration

Year: 2011
Type: article
Study design: Observational Study
Abstract: BACKGROUND: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. METHODS: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. RESULTS: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively). CONCLUSION: Chlamydia and gonorrhoea may infect the prostate of some infected men.
DOI: 10.1038/bjc.2011.271
Authors: S Sutcliffe, R L Nevin, R Pakpahan, D J Elliott, S R Cole, A M De Marzo, C A Gaydos, W B Isaacs, W G Nelson, L J Sokoll, J M Zenilman, S B Cersovsky, E A Platz
Institutions: Washington University in St. Louis, Alvin J. Siteman Cancer Center, Johns Hopkins University, Johns Hopkins Medicine, University of North Carolina at Chapel Hill, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Defense Center for Public Health - Aberdeen
Language: English
Subfield: Microbiology
Open Access status: hybrid
Estimated APC paid: $5,190
OpenAlex ID: W2167969743
FWCI: 0.523
Cites: 14
Cited by: 29
Related to: 10