Year: 2013
Type: article
Abstract: Knowledge about the pathogenesis and pathophysiology of chronic obstructive pulmonary disease (COPD) has advanced dramatically over the last 30 years. Unfortunately, this has had little impact in terms of new treatments. Over the same time frame, only one new class of medication for COPD has been introduced. Even worse, the rate at which new treatments are being developed is slowing. The development of new tools for the assessment of new treatments has not kept pace with understanding of the disease. In part, this is because drug development tools require a regulatory review, and no interested party has been in a position to undertake such a process. In order to facilitate the development of novel tools to assess new treatments, the Food and Drug Administration, in collaboration with the COPD Foundation, the National Heart Lung and Blood Institute and scientists from the pharmaceutical industry and academia conducted a workshop to survey the available information that could contribute to new tools. Based on this, a collaborative project, the COPD Biomarkers Qualification Consortium, was initiated. The Consortium in now actively preparing integrated data sets from existing resources that can address the problem of drug development tools for COPD.
Institutions: University of California, Los Angeles, The Lundquist Institute, Harbor–UCLA Medical Center, Harvard University, Temple University, National Heart, Lung, and Blood Institute, Innovate UK, University of London, University of Cambridge, COPD Foundation, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Royal Brompton Hospital, University of Nebraska Medical Center, University of Pittsburgh, GlaxoSmithKline (United States), University Hospitals Birmingham NHS Foundation Trust, Columbia University, University of Manchester
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2168008044