Counteracting the enzymatic activity of dipeptidylpeptidase 4 for potential therapeutic advantage, with an emphasis on cord blood transplantation
Year: 2013
Type: review
Abstract: Dipeptidylpeptidase (DPP) 4, also known as CD26, is an enzyme present on the surface of a number of different cell types. It is also found within cells and as a soluble protein in body fluids. It can specifically truncate proteins at the penultimate N-terminus residue for some amino acids, such as alanine, proline, serine, and perhaps others. DPP4 has been implicated in regulating the in vitro and in vivo functional activities of a number of hematopoietically active molecules, and this information, along with that on inhibition of DPP4, has been studied in efforts to enhance hematopoietic cell transplantation (HCT), hematopoiesis after stress in mouse models, and in the clinical setting of single-unit cord blood (CB) HCT. This article reviews the current status of this compound's effects on regulatory proteins, the field of CB HCT, a potential role for modulating DPP4 activity in enhancing single-unit CB HCT in adults, and future aspects in context of other cellular therapies and the area of regenerative medicine.
Author: Hal E. Broxmeyer
Institution: Indiana University School of Medicine
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $500
Awards: Mechanisms of Synergistic Regulation of Stem/Progenitors, Regulating hematopoietic stem cells and hematopoiesis for clinical efficacy, Cytokine Enhancement of Myeloid Progenitor Cell Survival, Regulation of Hematopoietic Cell Production, G5700285684, Enhancing Engraftment of Cord Blood by CD26 Inhibition, G6456074905, Basic Sciences Studies on Gene Therapy of Blood Diseases
OpenAlex ID: W2168168743