Work

Cholangiocarcinoma pathogenesis: Role of the tumor microenvironment.

Year: 2012

Type: article

Abstract: Cholangiocarcinoma is a tumor that originates from the neoplastic transformation of the epithelial cells of the intrahepatic or extrahepatic bile ducts. This type of cancer is difficult to diagnose, extremely aggressive, and has very poor prognosis. It is also relatively resistant to chemotherapy and radiation therapy. Its pathogenesis is poorly understood, however it is known that the tumor microenvironment is a very important factor in the regulation of tumor angiogenesis, invasion, and metastasis. The current knowledge about the mechanisms by which these events are regulated as well as the role of the tumor microenvironment in the pathogenesis and classification of cholangiocarcinoma will be discussed.

Source: PubMed

Authors: Dinorah Leyva-Illades, Matthew McMillin, Matthew Quinn, Sharon Demorrow

Institution: Texas A&M Health Science Center

Language: English

Topic: Cholangiocarcinoma and Gallbladder Cancer Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Awards: The Role of Progranulin in Cholangiocarcinoma Growth, Endocannabinoid Regulation of Cholangiocarcinoma Cell Growth