Work

Controlling Epileptiform Activity with Organic Electronic Ion Pumps

Year: 2015

Type: article

Abstract: In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

Source: Advanced Materials

DOI: 10.1002/adma.201500482

Authors: Adam Williamson, Jonathan Rivnay, Loïg Kergoat, Amanda Jonsson, Sahika Inal, Ilke Uguz, Marc Ferro, Anton Ivanov, Theresia Arbring Sjöström, Daniel T. Simon, Magnus Berggren, George G. Malliaras, Christophe Bernard

Institutions: Inserm, Aix-Marseille Université, Linköping University

Language: English

Topic: Neuroscience and Neural Engineering

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Science Foundation, Fondation de l'Avenir pour la Recherche Médicale Appliquée, European Commission, Agence Nationale de la Recherche, VINNOVA, Fondation pour la Recherche Médicale, Knut och Alice Wallenbergs Stiftelse, Vetenskapsrådet, Division of Materials Research

Awards: Ion Bipolar Chemical Circuits, G2613435631, G2639878582, G3207356259, Therapy and Diagnostics based on Organic BioElectonics, G393177772, Multifunctional implantable probes based on conducting polymer devices, G5478067435, G5702163051, Targets and biomarkers for antiepileptogenesis, G6860297198, Patterned Polymer Brushes as the Basis of Shape Selected Molecular Objects, G8765133162

OpenAlex ID: W2168285845

FWCI: 7.55

Cites: 42

Cited by: 176

Related to: 10