Plasmodium falciparum Merozoite Surface Antigen, PfRH5, Elicits Detectable Levels of Invasion-Inhibiting Antibodies in Humans
Year: 2013
Type: article
Abstract: Plasmodium falciparum is an intracellular protozoan parasite that infects erythrocytes and hepatocytes. The blood stage of its life cycle causes substantial morbidity and mortality associated with millions of infections each year, motivating an intensive search for potential components of a multi-subunit vaccine. In this study, we present data showing that antibodies from natural infections can recognize a recombinant form of the relatively conserved merozoite surface antigen, PfRH5. Furthermore, we performed invasion inhibition assays on clinical isolates and laboratory strains of P. falciparum in the presence of affinity purified antibodies to RH5 and show that these antibodies can inhibit invasion in vitro.
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Howard Hughes Medical Institute, Boston Children's Hospital, National Institutes of Health, Centers for Disease Control and Prevention, National Institute of Allergy and Infectious Diseases, Fogarty International Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1585209081, G518948582, Molecular analysis of erythrocyte invasion in malaria isolates from Senegal, MOLECULAR AND IMMUNOLOGIC ROLES OF P. FALCIPARUM INVASION LIGAND POLYMORPHISMS, Epidemiology of Infectious Diseases, Child Health Research Career Development Award (CHRCDA) Program (K12), Pediatric Scientist Development Program
OpenAlex ID: W2168341480